FFPE Tissue Block Uses

FFPE Tissue Block Uses

FFPE is a great commodity to the research and medical field as it is an inexpensive and easy way to store and archive tissue specimens. It also preserves the integrity of the specimen for a long time and can therefore be used retrospectively in many studies which reduces the time needed to track down specific tissues that fit the criteria of the study. 

An Overview of Genetic Testing in 2017

An Overview of Genetic Testing in 2017

Concert Genetics is a company that has collected information on 69,105 Genetic Testing Units (GTUs) that are active and available for ordering as of March 2017. Of these, there are 59,531 that assay a single gene or analyte, 8535 that are panels which assay multiple genes or analyses, 959 exome or genome that assay the entire genome sequence, and 79 that are non-invasive prenatal tests. 

Why Liquid Biopsy May Be Replacing The Tissue Biopsy

Why Liquid Biopsy May Be Replacing The Tissue Biopsy

Simply put, for most patients, a tissue biopsy can be costly, painful, and potentially risky.

Regardless of the challenges in obtaining adequate tissue for biopsy purposes, minimally invasive technologies have managed to:

  • Capture genomic contents of tumor in fluids
  • Combine sensitive genotyping assays

Hence, the potential role of “liquid biopsy” is now being evaluated as an alternative for tissue biopsy.

3 Methods of Protein Extraction in FFPE Samples

 3 Methods of Protein Extraction in FFPE Samples

Due to increased efforts to develop more effective cancer therapies, there is an increased demand for specimens that allow molecular analysis of tumor tissues and isolation of the proteins. This means that a safe, efficient, reproducible and cost-effective process of deparaffinization is required. Releasing proteins from FFPE specimens can be daunting as the extensive molecular crosslinking that occurs through formalin fixation lowers the efficiency of protein extraction and may also interfere with immunoreactivity. This warrants the development of more advanced and efficient extraction methods.